Actions of pituitary hormones beyond traditional targetsJuly 2, 2018
Identifying new roles for pituitary hormones, Mone Zaidi et al have landed upon the action of thyroid-stimulating hormone (TSH) on bone. Genetic and pharmacologic FSH suppression increases bone mass and reduces body fat, laying the framework for targeting the FSH axis for treating obesity and osteoporosis simultaneously with a single agent. TSH and oxytocin are also expressed in bone cells, providing local paracrine and autocrine networks for the regulation of bone mass. The newly described signaling pathways appear not to have identical mechanisms to traditional endocrine targets, suggesting a pituitary–bone and pituitary– adipose axis. Once this axis is perturbed, it can lead to diseases such as obesity and osteoporosis.