miRNA alteration to control type-2 diabetesOctober 10, 2018
Regulation of miRNA becomes a potential target for therapeutic interventions towards the treatment of type-2 diabetes and obesity-associated metabolic syndrome. miRNA has been increasingly known to play an important role in the regulation of various cellular and metabolic processes. Based on this aspect, a team of scientists from CSIR-CDRI, Lucknow, CSIR-IHBT, Palampur and CSIR-IGIB, New Delhi,investigated the effect of altered expression of miRNA in insulin resistant adipocyte models developed from human mesenchymal stem cells (hMSC). The study found that overexpression of miR-876-3p in insulin resistant cells decreased the adiponectin hormone levels, which elevated insulin resistance by altering specific performed adipokine expression. Lentivirus-mediated overexpression and suppression studies were performed in insulin-resistant adipocytes differentiated from hMSC and high fat-diet fed C57BL/6 obese mice models to validate the findings in vivo, which were shown to ameliorate insulin resistance with inhibition of miR-876-3p. The study provides a new perspective and the findings show greater implications in the development of therapeutic targets for type-2 diabetes.
Journal of Endocrinology (2018) 239, 1–17 https://doi.org/10.1530/JOE-17-0387