Manipal doctors identify `pp’ blood phenotype

September 12, 2018 0 By CH Unnikrishnan

Arare blood group called ’pp’ or ’P null’ has been identified in India by a team of doctors in Manipal.

The team, led by Dr Shamee Shastry from the blood bank of Kasturba Medical College, Manipal landed upon the rare blood group as they were looking for compatible blood for a patient who needed urgent transfusion.

Even after cross matching with more than 80 units, the doctors could not find a compatible blood unit for the patient. Following extensive immunohematology workup, the samples were referred to International Blood group Reference Laboratory (IBGRL), Bristol, UK for serological testing.

The reference laboratory helped to confirm that the patient’s cells had the rare ‘pp’ phenotype.

“The patient had a very rare ‘P null’ blood group and anti-PP1Pk antibody in his blood that has a potential to cause acute intravascular hemolytic reaction in case of incompatible blood transfusion,” said Dr. Shamee Shastry, professor and the head of the department of Immunohematology and Blood Transfusion in a press release.

Rare donor registry will be of great help in managing such cases. The antibody is also known to cause recurrent abortions in women. Finding compatible units for such cases is a near impossible task without a well-established rare-donor panel, she added.

A blood type is considered rare if it is found in fewer than 1 in 1,000 people. A person is said to have rare blood group when he lacks high-frequency antigens or multiple common antigens, according to the release.