Tear film may help assess diabetic neuropathy

Tear film may help assess diabetic neuropathy

Shyam Sunder Tummanapalli et al found that peripheral neuropathy, which is often the earliest sign of diabetes, could be traced in the tear film. Researchers found that people with type 1 diabetic peripheral neuropathy had reduced levels of a protein known as ‘substance P’ (SP) in their tear film. Scientists evaluated changes that occur in the concentrations of substance P and calcitonin gene-related peptide (CGRP) in tears as a result of corneal denervation. The experiment tested the concentration of these neuropeptides in the tear film of people with type 1 and type 2 diabetes compared to control groups. Participants with type 1 diabetes showed significantly reduced amounts SP peptide in their tear film, while CGRP remained unchanged. However, there was not any indication observed in type 2 diabetes. Researchers suggest that tear film protein SP may provide a potential non-invasive biomarker for assessing neuropathy in type 1 diabetic patients.

Source: The Ocular Surface 30 August 2019 DOI: 10.1016/j.jtos.2019.08.010  https://doi.org/10.1016/j.jtos.2019.08.010  

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