Luca Zazzeron et al developed an extracorporeal membrane oxygenator for blood exposure to phototherapy to enhance the removal of carbon monoxide in CO poisoning. The researchers found that exposing blood to visible light enhanced the rate of CO elimination in vivo. They then developed a membrane oxygenator with optimal characteristics to facilitate exposure of blood to visible light and tested the device in a rat model of CO poisoning, with or without lung injury. The extracorporeal removal of CO
with phototherapy (ECCOR-P) doubled the rate of CO elimination in CO-poisoned rats with normal lungs. In CO-poisoned rats with acute lung injury, treatment with ECCOR-P increased the rate of CO removal by three times compared to ventilation with 100% oxygen alone and was associated with improved survival. Findings show that extracorporeal CO photo-removal device, in clinical use may provide additional benefits for CO-poisoned patients, especially for those with acute lung injury.
Source: Science Translational Medicine 09 Oct 2019: Vol. 11, Issue 513, eaau4217 DOI:10.1126/scitranslmed.aau4217 https://stm.sciencemag.org/content/11/513/eaau4217