Researchers from the Massachusetts Institute of Technology has recently fabricated a new removable bioadhesive tape that allows surgeons to seal internal wounds and tears of organs as a replacement for sutures. The tape can be used to seal incisions of lungs and intestines or affix implants and other medical devices to the surfaces of organs such as the heart.
The team had previously developed a similar tape but was devoid of the ability to be detached without causing tissue damage. Now, the research team has developed a new version of the tape that can be readily detached from the tissue surface by application of a liquid solution.
The original adhesive which included polyacrylic acid and N-Hydroxysuccinimide esters, which could form long-lasting bonds with the tissue surface was augmented with disulfide linker molecules that allows the adhesive to be easily severed when exposed to a reducing agent.
Upon spraying the reducing solution the covalent bonds between the adhesive and surface proteins in the tissue can be broken allowing it to be readily peeled from a tissue surface, regardless of how long it has been in place, says the researchers.
The removal is painless and does not cause tissue damage making the tape safer and easier to use, allowing surgeons to remove it once tissue healing has completed or adjust the tape’s position if required, avers the scientists.