Metabolic disorders linked to development of kidney stones: Study

Metabolic disorders linked to development of kidney stones: Study

Nephrolithiasis (kidney stone) is highly prevalent among patients with metabolic syndrome, finds a recent hospital-based study published in the Journal of the Association of Physicians of India.

The study also found a significant correlation between risk factors of nephrolithiasis and various components of metabolic syndrome.

Dr Ritu Karoli and team from the super speciality medical institute Dr Ram Manohar Lohia Institute of Medical Sciences (RMLIMS), Lucknow, conducted the study with regard to the rise in the incidence of kidney stone coinciding with the increasing epidemic of type 2 diabetes, metabolic syndrome, and obesity in recent decades.

The hospital-based, case-control study included a hundred patients of metabolic syndrome diagnosed according to International Diabetes Federation (IDF) criteria.

Patients with metabolic syndrome had significantly higher uricosuria, hypercalciuria, oxaluria and hypocitraturia. The prevalence of risk factors of kidney stone was also higher in patients with metabolic syndrome.

The most prevalent was low urinary pH in 40% of patients with a mean pH of 5.8±1.6. Amongst other factors, 33% had hyperuricemia, 29% had hypercalciuria, 15% had oxaluria 13% had hypocitraturia and 10% had hyperuricosuria.

“Our findings provide evidence of an association between risk factors of nephrolithiasis and metabolic syndrome and suggest that nephrolithiasis may be a systemic disorder representing the interaction of multiple metabolic derangements,” wrote the authors.