A team of researchers from the University of Michigan, developed a portable device that can non-invasively measure brain metabolism to help make faster and more certain diagnosis of concussions.
The system named- Super-Continuum Infrared Spectroscopy of Cytochrome-C-Oxidase (SCISCCO), works by utilising infrared light pulses.
Using IR light, SCISCCO analyses brain metabolism by interacting with the mitochondrial enzyme cytochrome C oxidase (CCO) which is known to decrease when cells suffer from damage. The all-fibre integrated, supercontinuum light source can simultaneously measure both the CCO and blood oxygenation markers of neural metabolism, say the researchers.
Apart from detecting oxygenation levels, the device allows the user to know if the oxygen is being utilised properly by the brain cells.
The study used wavelengths of IR between 750 nm and 900 nm to excite the CCO which could give a strong response. The SCISCCO system was validated by confirming the near-infrared (NIR) spectrum of CCO in vitro. The measured responses of oxygenation and CCO responses in human participants were compared to data from the literature.
The use of all-fibre-integrated supercontinuum light source has the potential of being a practical, cost-effective, portable, noninvasive means of monitoring brain and organ oxygenation and metabolism in medical facilities, said the researchers.
The study was presented at the SPIE Photonics West BiOS, held in San Francisco on February 2, 2020.