Yahia Al-Jebari et al evidenced a higher risk of prostate cancer in later life among men who have taken fertility treatment. The team looked at 1.2 million pregnancies in Sweden for over 20 years. Fathers were grouped according to fertility status by mode of conception of in vitro fertilisation (IVF), intra-cytoplasmic sperm injection (ICSI), and natural conception.
The findings showed that men who became fathers by participating in intra-cytoplasmic sperm injection (ICSI) had a 64% higher risk of developing prostate cancer over the succeeding two decades compared with men who did not receive assisted reproduction therapy. Men who received assisted reproduction therapy had a 30% greater risk of developing prostate cancer during follow-up. Men who achieved fatherhood through assisted reproduction techniques, particularly through ICSI, are at increased risk for early-onset prostate cancer. The findings suggest long term follow-up for prostate cancer may be beneficial in the risk group.
Source: BMJ 2019;366: l5214 25 September 2019 doi: https://doi.org/10.1136/bmj.l5214