Stroke study finds mouth bacteria in brain clots

August 5, 2019 0 By FM

Olli Patrakka et al demonstrated the presence of oral bacterial DNA in thrombus aspirates of patients with acute ischemic stroke (AIS) suggesting a possible role for poor dental care in the cause of cerebrovascular disease. The study showed common presence of bacterial DNA from viridans streptococci in the aspired thrombi of patients. Of the study population involving 75 patients, 69.3% (n=52) were men and 30.7% (n=23) were women. The study utilised real‐time quantitative PCR (qPCR) to detect bacterial DNA from thrombi that have been collected by stent retriever technique from the cerebral arteries of patients with AIS. Of the participants who underwent thrombectomy for treatment of acute stroke, 84.0% (n=63) of aspirated thrombi were positive for bacterial DNA in qPCR compared with 16.0% (n=12) of bacteria‐negative thrombi. In addition, 78.7% (n=59) of aspirated thrombi were positive for Streptococcus species, mainly the S mitis group. All thrombi were negative for bacterial DNA of both Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. The findings suggest that viridans streptococci may have a role in the cause of cerebrovascular disorder. Researchers emphasize practice of regular dental care in the primary prevention of acute ischemic stroke.

Source: Journal of the American Heart Association. 4 Jun 2019