Candida infections in brain may impair memoryMarch 7, 2019
Yifan Wu et al reported that the common yeast Candida albicans could cross the blood-brain barrier to trigger inflammatory response leading to the formation of granulomatous structures and mild memory impairment. The study reveals a resemblance between the granuloma-type structures with plaques found in Alzheimer’s disease. The researchers injected a dose of 25,000 C. albican cells into a mouse model. The yeasts showed to cross the blood-brain barrier triggering the microglia. They also produced a number of molecules that mediated inflammatory response. This led to capture of yeasts within a granule-type structure in the brain called fungus-induced glial granuloma (FIGG). Resultant accumulation of amyloid precursor protein within the periphery of the granuloma revealed the possibility for fungal involvement in the development of neurodegenerative diseases. The mice cleared the infection in 10 days leaving active microglia and FIGG for about 21 days. They also displayed mild memory impairment that resolved with fungal clearance. The research supports a need for future studies on long-term neurological consequences of sustained C. albican infection.
Source: Nature Communications, Volume 10, Article number: 58 (2019) Published: 04 January 2019 https://www.nature.com/articles/s41467-018-07991-4