Lateral OFC stimulation found effective in treating mood disorders

February 5, 2019 0 By FM

Rao et al unveiled an effective target in the brain for electrical stimulation to improve mood in people suffering from depression. Using direct neurophysiological recordings, the scientists revealed that unilateral stimulation of the lateral orbitofrontal cortex
(OFC) produced acute, dose-dependent improvement among patients who had baseline depression. The study was performed in a small cohort of 25 individuals who suffered from epilepsy. Intracranial electrodes were implanted in the participants for seizure localization by subjecting to continuous electroencephalography (iEEG). Mood-state changes were assessed with the iEEG recordings which showed acute improvement in the mood of the patients. The study showed lateral OFC as a promising new stimulation target with therapeutic potential suggesting to set the stage for next generation of stimulation therapies.

Source: Current Biology VOLUME 28, ISSUE 24, P3893-3902.E4, DECEMBER 17, 2018