Polyphenols inhibit amyloid-beta aggregationJanuary 14, 2019
Ross S. Mancini et al found evidence revealing the neuroprotective role of coffee against developing Alzheimer’s and Parkinson’s disease by reducing the aggregation of misfolded proteins involved in it. The study showed a remarkable effect of various polyphenolic compounds found in brewed coffee to alter the aggregation profile of amyloid-beta, tau and alpha-synuclein found associated with dementia. Three different types of coffee including light roast, dark roast, and decaffeinated dark roast and six different coffee components were analysed in the study. Of the various coffee components investigated, phenylindane was the only compound found to be a potent inhibitor of both amyloid-beta and tau aggregation, unlike other components. The study is the first to report on the aggregation inhibition activity of phenylindane for Ab, tau and a-synuclein. The researchers are currently involved in a further investigation on the cell and animal models for AD and PD based on the promising observations of the study.
Frontiers in Neuroscience, 2018; 12 October 2018DOI: 10.3389/fnins.2018.00735