E-nose system to sniff out cancer in blood samples

July 9, 2021 0 By FM

AT Charlie Johnson et al have developed a high-throughput screening test for cancer based on the analysis of volatile organic compounds (VOCs) in blood. The electronic olfaction- “e-nose”- system is equipped with novel nanosensors that are calibrated to detect and distinguish vapour characteristics of components in plasma samples. The test could distinguish between pancreatic and ovarian cancer and their benign forms effectively. The study analysed samples from 93 different individuals including 20 patients with ovarian cancer, 20 with benign ovarian tumours, and 20 age-matched controls with no cancer, as well as 13 patients with pancreatic cancer, 10 patients with benign pancreatic tumour, and 10 controls. The samples were analysed using a 10-channel nano e-nose system based on single-stranded DNA-coated single-walled carbon nanotube (DNA-NT) vapour sensors. The results were obtained within a test time of approximately 20 minutes per sample. The DNA-NT sensor array was able to discriminate the VOCs from ovarian cancer with 95% accuracy and pancreatic cancer with 90% accuracy. The algorithm could also help identify tumours at both advanced and the earliest stages paving way for a new diagnostic approach.

Source: Journal of Clinical Oncology| May 28, 2021, | Volume 39, Issue no. 15_suppl DOI: 10.1200/JCO.2021.39.15_suppl.5544 |https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.5544