Implantable hydrogel helps neurons recover after TBI

June 10, 2021 0 By FM

Charles-Francois V Latchoumane et al showed that synthetic neurotrophic factor functionalised chondroitin sulfate (eCS) matrices, when implanted into brain regions, mediated significant structural and functional recovery after severe traumatic brain injury (sTBI).

The team analysed the long-term outcomes of implanting the sulfated eCS matrices which were laden with fibroblast growth factor 2 (FGF2) and brain-derived neurotrophic factor (BDNF). The study conducted in mice models showed that the brain-mimetic eCS matrices, when implanted into M1 region acutely after sTBI, cartilage. Using FRESH and in vitro chondrogenesis, the team fabricated tissue-engineered nasal cartilage from combining bovine type I collagen hydrogel and human nasoseptal chondrocytes. The printed structures mimicked human nasal cartilage in terms of its mechanical, molecular enhanced cellular repair and gross motor function recovery in 20 weeks. Animals subjected to M2 region injuries followed by eCS matrix implantations showed significant recovery of “reach-to-grasp” function. The results were attributed to an increase in volumetric vascularisation, activity-regulated cytoskeleton (Arc) protein expression, and perilesional sensorimotor connectivity. The findings indicated that eCS matrices implanted acutely after sTBI supported complex cellular, vascular, and neuronal circuit repair chronically after the injury.