Arie Levine et al demonstrated that Crohn’s disease exclusion diet (CDED) may be used as an effective and well-tolerated, first-line therapy for children with mild-to-moderate Crohn’s disease (CD). The researchers compared exclusive enteral nutrition (EEN) which is a complete liquid diet, excluded of normal dietary components used to treat children with active Crohn’s disease (CD), with the CD exclusion diet (CDED). The CDED is a whole-food diet combined with EEN designed to reduce dietary exposure to foods that might negatively impact the microbiome, the intestinal barrier and innate immunity. Researchers conducted a 12-week trial involving 78 children with CD. The participants were randomly assigned to receive either the CD exclusion diet (40) or EEN alone (38). The researchers observed similar outcomes in both groups regarding disease activity, decrease in inflammation and sustained steroid-free remission. However, the CDED was found better tolerated by patients with 97.5% tolerance (39/40) compared with 73.7% in the ENN group (28/38). The study reveals that Crohn’s disease exclusion diet plus partial enteral nutrition can be provided for 12 weeks as first-line therapy in treating mild-to-moderate Crohn’s disease.
Source: Gastroenterology 4 June 2019 DOI: https://doi.org/10.1053/j.gastro.2019.04.021