Mouthwash containing at least 0.07 percent cetylpyridinium chloride (CPC) showed promising signs of reducing transmission of the coronavirus by reducing the viral load, finds scientists at Cardiff University.
The preliminary results come ahead of a clinical trial on patients at the University Hospital of Wales in Cardiff to find out whether mouthwash can reduce coronavirus in a patient’s saliva. The findings are expected to be published in early 2021. The study is yet to be peer-reviewed.
The scientists showed that commonly used mouthwashes were able to kill the coronavirus within 30 seconds of exposure in laboratory conditions. However, this does not mean they would be able to treat the virus within the body or act as a cure, they added.
The researchers from Cardiff’s Systems Immunity Research Institute tested how effective a handful of mouthwashes containing ethanol/essential oils, cetylpyridinium chloride and povidone-iodine (PVP-I) were at eradicating the virus. They found that three of the mouthwashes they tried eradicated the virus completely. Out of these three products, two contained at least 0.07% CPC and the third contained 23% ethanol with ethyl lauroyl arginate (LAE).
“This study adds to the emerging literature that several commonly available mouthwashes designed to fight gum disease can also inactivate the SARS-CoV-2 coronavirus (and other related coronaviruses) when tested in the laboratory under conditions that are designed to mimic the oral/nasal cavity in a test tube,” said Dr Richard Stanton, lead author on the study.
The results of the upcoming clinical trials are expected early next year. It was important to see how long the virus lasts for in the throat and whether
mouthwashes could help reduce transmission, for example in dental investigations, mouth/throat examinations by clinicians, or short-term contacts with vulnerable patients or other individuals, said Dr Stanton.
Although this in-vitro study is very encouraging and is a positive step, more clinical research is now clearly needed, said the researchers.